Summary
Perfusion improves engineered tissues by enhancing nutrient and oxygen delivery. This study introduces a lightweight (<10 lb) portable perfusion system FluidON and CO2 cell culture incubator system CultureON capable of maintaining continuous flow under standard incubation conditions. The device generates physiologically relevant interstitial flow rates and ensures uniform nutrient distribution, as confirmed by computational modeling. When tested with bioengineered tissue patches, the system maintained cell viability, improved spatial organization, strengthened the tissue matrix, and slowed hydrogel degradation. Overall, the system enables mobile perfusion and incubation, offering a promising tool for advancing tissue maturation and bioengineering research.
Full article link
https://doi.org/10.3390/bioengineering12050554
This article belongs to the Special Issue The New Frontiers of Artificial Organs Engineering
Leading organizations
The study was jointly performed by University of Chicago (Dr. Narutoshi Hibino laboratory) and the technical team at 37degrees, Inc.
Product relevance
FluidON 100